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2013 Nobel Prize in Physiology or Medicine jointly awarded to James E. Rothman, Randy W. Schekman and Thomas C. Südhof, for  their discoveries of machinery regulating vesicle traffic, a major transport system in our cells

Monday, 07 October 2013
Americans James Rothman and Randy Schekman and Germany's Thomas Suedhof won the 2013 Nobel medicine prize for their work on how hormones are transported within and outside cells, giving insight into diseases such as diabetes and Alzheimer's.

For instance, insulin is manufactured and released into the blood and chemical signals called neurotransmitters are sent from one nerve cell to another. These molecules are transported around the cell in small packages called vesicles, Nobel writes in a press release.

The three Nobel Laureates have discovered the molecular principles that govern how this cargo is delivered to the right place at the right time in the cell.

Randy Schekman discovered a set of genes that were required for vesicle traffic. James Rothman  unravelled protein machinery that allows vesicles to fuse with their targets to permit transfer of cargo. Thomas Südhof revealed how signals instruct vesicles to release their cargo with precision.

Through their discoveries, Rothman, Schekman and Südhof have revealed the exquisitely precise control system for the transport and delivery of cellular cargo. Disturbances in this system have deleterious effects and contribute to conditions such as neurological diseases, diabetes, and immunological disorders.
by Scancomark.com / from Nobel Committee






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