2013 Nobel Prize in Physiology or Medicine jointly awarded to James
E. Rothman, Randy W. Schekman and Thomas C. Südhof, for their
discoveries of machinery regulating vesicle traffic, a major transport
system in our cells
Monday, 07 October 2013
Americans James Rothman and Randy Schekman and Germany's Thomas Suedhof
won the 2013 Nobel medicine prize for their work on how hormones are
transported within and outside cells, giving insight into diseases such as diabetes and Alzheimer's.
For instance, insulin is manufactured and released into the blood and
chemical signals called neurotransmitters are sent from one nerve cell
to another. These molecules are transported around the cell in small
packages called vesicles, Nobel writes in a press release.
The three Nobel Laureates have discovered the molecular principles that
govern how this cargo is delivered to the right place at the right time
in the cell.
Randy Schekman discovered a set of genes that were required for vesicle
traffic. James Rothman unravelled protein machinery that allows
vesicles to fuse with their targets to permit transfer of cargo. Thomas
Südhof revealed how signals instruct vesicles to release their cargo
Through their discoveries, Rothman, Schekman and Südhof have revealed
the exquisitely precise control system for the transport and delivery
of cellular cargo. Disturbances in this system have deleterious effects
and contribute to conditions such as neurological diseases, diabetes,
and immunological disorders.
by Scancomark.com / from Nobel Committee
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