Karo Bio enters research collaboration on fibrotic diseases with 4D Science
Monday, 23 September 2013
Pharmaceutical company, Karo Bio AB announces that it had entered
into a research collaboration with 4D Science GmbH to develop novel
treatments for fibrotic diseases, based on a recent discoveries made by
Dr. Jörg Distler.
Dr. Jörg Distler’s research group has recently discovered that a
specific nuclear receptor plays a key role in the pathogenesis of
fibrotic diseases. The findings may be of therapeutic benefit to
patients suffering from such diseases. There are currently no effective
treatments of fibrosis available.
“We look forward to collaborating with Jörg Distler and his team on
this novel approach to fibrosis. This is an area with very large unmet
medical needs and where new ideas up until now have been scarce.
Together, we will be able to speed up the development of the project
significantly,” says Karo Bio’s CEO Per Bengtsson.
4D Science GmbH is a biotechnology company founded by Dr. Jörg Distler
at the University of Erlangen-Nuremberg. Dr. Jörg Distler, University
Hospital of Erlangen-Nuremberg and CEO of 4D Science GmbH, is an
internationally recognized authority in translational fibrotic disease
research. 4D Science has a broad range of fibrotic disease models that
are widely used by the pharmaceutical industry to evaluate drug
The collaboration will initially focus on generating additional data
further validating the nuclear receptor as a target in fibrosis and
demonstrating its druggability. Karo Bio will carry out the
collaboration work within the scope of its current operations. The two
parties will share costs and rewards for the collaboration program.
Fibrosis is the accumulation of excess fibrous connective tissue in an
organ or tissue. Cardiac, renal, and pulmonary fibrosis together with
hepatic cirrhosis contribute to approximately 40 per cent of deaths in
the industrial world. A common mechanism for fibrotic diseases
regardless of which organs are involved, is excessive accumulation of
collagen-rich scar tissue.
In severe forms of fibrosis, uncontrolled deposition of scar tissue
leads to organ failure and death. Despite the enormous economic and
societal impact of fibrotic diseases, safe and effective treatments are
News Sources: Press release from Karo Bio
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